4′-Fluoro-nucleosides and nucleotides: from nucleocidin to an emerging class of therapeutics
Chemical Society Reviews Pub Date: 2022-12-06 DOI: 10.1039/D2CS00762B
Abstract
The history and development of 4′-fluoro-nucleosides is discussed in this review. This is a class of nucleosides which have their origin in the discovery of the rare fluorine containing natural product nucleocidin. Nucleocidin contains a fluorine atom located at the 4′-position of its ribose ring. From its early isolation as an unexpected natural product, to its total synthesis and bioactivity assessment, nucleocidin has played a role in inspiring the exploration of 4′-fluoro-nucleosides as a privileged motif for nucleoside-based therapeutics.
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Journal Name：Chemical Society Reviews
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CAS no.: 89640-58-4
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