Site-selective amination and/or nitrilation via metal-free C(sp2)–C(sp3) cleavage of benzylic and allylic alcohols?
Chemical Science Pub Date: 2022-04-05 DOI: 10.1039/D2SC00758D
Abstract
Benzylic/allylic alcohols are converted via site-selective C(sp2)–C(sp3) cleavage to value-added nitrogenous motifs, viz., anilines and/or nitriles as well as N-heterocycles, utilizing commercial hydroxylamine-O-sulfonic acid (HOSA) and Et3N in an operationally simple, one-pot process. Notably, cyclic benzylic/allylic alcohols undergo bis-functionalization with attendant increases in architectural complexity and step-economy.
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Journal Name：Chemical Science
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CAS no.: 89640-58-4
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