A three-component difunctionalization of N-alkenyl amides via organophotoredox radical-polar crossover?
Chemical Communications Pub Date: 2022-08-01 DOI: 10.1039/D2CC04101D
Abstract
Herein, we report a three-component organophotoredox coupling of N-alkenyl amides with α-bromocarbonyls and various nucleophiles. This transition metal-free difunctionalization protocol installs sequential C–C and C–Y (Y = S/O/N) bonds in alkenes. This reaction works with terminal and internal alkenes containing both cyclic and acyclic amides via radical-polar crossover.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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