Investigation of metformin hydrochloride–bovine serum albumin interaction by narrow-bore capillary zone electrophoresis?
Chemical Communications Pub Date: 2022-02-02 DOI: 10.1039/D1CC07067C
Abstract
A narrow-bore capillary (inner diameter = 2 μm) zone electrophoresis method was developed to study the interaction between metformin hydrochloride and bovine serum albumin. Free metformin hydrochloride, free bovine serum albumin, and their complex were completely separated in a volume of tens of picoliters. The association constant (Ka = 1.04 × 103 L mol?1) and the number of binding sites (n = 0.9789) were then obtained.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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