Palladium-catalyzed cross-coupling of unreactive C(sp3)–H bonds with azole C(sp2)–H bonds by using bromide as a traceless directing group?
Chemical Communications Pub Date: 2022-05-12 DOI: 10.1039/D2CC01944B
Abstract
A palladium-catalyzed intermolecular cross-coupling of unreactive C(sp3)–H bonds and azole C(sp2)–H bonds with bromide as a traceless directing group is described. The judicious selection of the bulky and electron-rich phosphine ligand is the key for the success of this cascade process. The protocol features a broad substrate scope, excellent regioselectivity, and good functional group tolerance.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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