Improvement of (S)-selective imine reductase GF3546 for the synthesis of chiral cyclic amines?
Chemical Communications Pub Date: 2022-11-07 DOI: 10.1039/D2CC05116H
Abstract
An engineered (S)-selective imine reductase from Streptomyces sp. GF3546 (SIR46) showed twice the activity of the wild type and high thermostability at 50 °C. Using a biocatalyst based on SIR46, we investigated the activity toward high-concentration 2-methyl-1-pyrroline up to 500 mM, conversion rates of other imines, and reductive amination activity.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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