A fluorescent probe for alkylating agents and its quantification of triflate as a genotoxic impurity?
Chemical Communications Pub Date: 2023-01-24 DOI: 10.1039/D2CC06221F
Abstract
The responses of a reaction-based fluorescent probe BI-Py towards alkyl halide, epoxide, carbonate, sulfate, sulphonate and triflate were evaluated and the probe achieved selective detection of ethyl triflate in acetonitrile with a LOD of 1.08 μM. BI-Py exhibited great potential for detecting triflate as a genotoxic impurity in drug substances.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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