Design and synthesis of a new family of planar and central chiral ferrocenyl phosphine ligands?

Chemical Communications Pub Date: 2023-01-26 DOI: 10.1039/D2CC06492H

Abstract

A family of planar chiral indene-fused ferrocenes were prepared through an intramolecular asymmetric C–H arylation in excellent yields (up to 99%) with excellent enantioselectivities (up to 99% ee). They were thereafter successfully transformed to chiral ferrocenyl phosphines, featuring both planar and central chiralities, in good yields (up to 83%) and excellent diastereoselectivities (up to 99% de) through highly diastereoselective phosphination. This protocol offers a general method for planar and central chiral ferrocenyl phosphines. The potential applications of the newly developed ligands were demonstrated by a Pd-catalyzed enantioselective allylic alkylation reaction, in which high enantioselectivity (92% ee) and good yield (89%) were obtained.

Graphical abstract: Design and synthesis of a new family of planar and central chiral ferrocenyl phosphine ligands
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