Enantioselective resolution of two model amino acids using inherently chiral oligomer films with uncorrelated molecular structures?

Chemical Communications Pub Date: 2023-07-14 DOI: 10.1039/D3CC02258G

Abstract

Preferential crystallization induced by chiral surfaces is an interesting alternative to isolate enantiopure antipodes. Herein, we take advantage of the outstanding enantiorecognition capabilities of inherently chiral oligomers to induce an enantioselective crystallization process. We exemplify this strategy with two amino acid model molecules, asparagine and glutamic acid, having a completely uncorrelated structure with respect to the template. This illustrates the versatility of the approach with potential applications in the resolution of pharmaceutical compounds.

Graphical abstract: Enantioselective resolution of two model amino acids using inherently chiral oligomer films with uncorrelated molecular structures
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