Asymmetric synthesis of a highly functionalized enantioenriched system close to thapsigargin framework?

Organic & Biomolecular Chemistry Pub Date: 2012-08-06 DOI: 10.1039/C2OB26194D

Abstract

A straightforward approach to a highly functionalized enantioenriched bicyclo[5.3.0]decadienone system close to the thapsigargin framework has been achieved. The developed synthetic route involves two main stages: installation of the chains on either side of the quaternary center at C7 starting from a central enantiopure epoxide and formation of the bicyclic octahydroazulene through subsequent Pauson–Khand annelation.

Graphical abstract: Asymmetric synthesis of a highly functionalized enantioenriched system close to thapsigargin framework
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