An approach to hyperolactone C and analogues using late stage conjugate addition on an oxonium ylide-derived spirofuranone?

Organic & Biomolecular Chemistry Pub Date: 2013-07-12 DOI: 10.1039/C3OB41251B

Abstract

A stereocontrolled synthesis of norphenyl hyperolactone C together with its utility as a direct precursor to the anti-HIV agent hyperolactone C and analogues by addition of organolithiums, are described. Preliminary studies to access this key building block in a catalytic enantioselective manner are also reported.

Graphical abstract: An approach to hyperolactone C and analogues using late stage conjugate addition on an oxonium ylide-derived spirofuranone
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