Analytical uses of charge-transfer complexes: determination of pure and dosage forms of piperazine

ANALYSTANALYST Pub Date: DOI: 10.1039/AN9840901277

Abstract

The charge-transfer interaction of piperazine with benzoquinone and its halo derivatives was used for the simple spectrophotometric determination of piperazine in chloroform medium. The sensitivity of the method and the time stability of the charge-transfer complexes were found to depend on the electron affinity of the quinones. The drug-base in different dosage forms was extracted into chloroform after alkali treatment and the piperazine was assayed. The method is sensitive and rapid and the base tolerates a wide variation of reagent concentration. The results compare well with the official BP method.

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