Weak coordinated nitrogen functionality enabled regioselective C–H alkynylation via Pd(ii)/mono-N-protected amino acid catalysis?
Chemical Communications Pub Date: 2020-08-14 DOI: 10.1039/D0CC04739B
Abstract
The exploration of weak coordinated amine derivative enabled regioselective C–H functionalization remains challenging due to the elusive achievement of reactivity and selectivity simultaneously. Herein, regioselective C–H alkynylation of various readily transformable nitrogen functionalities was developed with great efficiency, with the assistance of the mono-N-protected amino acid (MPAA) ligand via Pd(II) catalysis proceeding via 5, 6 and 7-membered palladacycle intermediates.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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