Toward transmembrane anionophores based on rigid bis(choloyl) conjugates: reversal of the ion selectivity by appended polyamines?

RSC Advances Pub Date: 2014-09-08 DOI: 10.1039/C4RA07390H

Abstract

A bis(choloyl) conjugate tethered with a bis(polyamine)-appending rigid linker was synthesized and found to efficiently promote the exchange of anions across egg-yolk L-α-phosphatidylcholine-based liposomal membranes. This is in sharp contrast to a previous finding that its analog having two monoamino groups acted as a cation/proton antiporter.

Graphical abstract: Toward transmembrane anionophores based on rigid bis(choloyl) conjugates: reversal of the ion selectivity by appended polyamines
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