The role of natural products in the prevention and treatment of pulmonary fibrosis: a review
Food & Function Pub Date: 2020-12-21 DOI: 10.1039/D0FO03001E
Abstract
Pulmonary fibrosis is an incurable end-stage lung disease and remains a global public health problem. Although there have been some breakthroughs in understanding the pathogenesis of pulmonary fibrosis, effective intervention methods are still limited. Natural products have the advantages of multiple biological activities and high levels of safety, which are important factors for preventing and treating pulmonary fibrosis. In this review, we summarized the mechanisms and health benefits of natural products against pulmonary fibrosis. These natural products target oxidative stress, inflammatory injury, epithelial–mesenchymal transition (EMT), fibroblast activation, extracellular matrix accumulation and metabolic regulation, and the mechanisms involve the NF-κB, TGF-β1/Smad, PI3K/Akt, p38 MAPK, Nrf2-Nox4, and AMPK signaling pathways. We hope to provide new ideas for pulmonary fibrosis prevention and treatment strategies.
Recommended Literature
- [1] Aggregation-induced growth and transformation of β-FeOOH nanorods to micron-sized α-Fe2O3 spindles Benjamin A. Legg,Luis R. Comolli,Hengzhong Zhang,Benjamin Gilbert,Erik Johnson,Jillian F. BanfieldCrystEngComm, 2014,16, 1451-1458 10.1039/C3CE40983J
- [2] An automatic method for the determination of anionic surface-active material in water Analyst, 1966,91, 113-118 10.1039/AN9669100113
- [3] An ionic liquid-based synergistic extraction strategy for rare earths? Yingbo Li,Nada Mehio,Huizhou Liu,Sheng DaiGreen Chem., 2015,17, 2981-2993 10.1039/C5GC00360A
- [4] An auto-correction laser photoacoustic spectrometer based on 2f/1f wavelength modulation spectroscopy Ke Chen,Shuai Liu,Liang Mei,Feng Jin,Bo Zhang,Fengxiang Ma,Yewei Chen,Hong Deng,Min Guo,Qingxu YuAnalyst, 2020,145, 1524-1530 10.1039/C9AN01799B
- [5] Aggregative growth of quasi-octahedral iron pyrite mesocrystals in a polyol solution through oriented attachment? CrystEngComm, 2016,18, 8823-8828 10.1039/C6CE01692H
- [6] Alternative synthesis of the anti-baldness compound RU58841? RSC Adv., 2014,4, 14143-14148 10.1039/C4RA00332B
- [7] An alternative biorefinery approach to address microalgal seasonality: blending with spent coffee grounds Andre Prates Pereira,Tao Dong,Eric P. Knoshaug,Nick Nagle,Ryan Spiller,Bonnie Panczak,Christopher J. Chuck,Philip T. PienkosSustainable Energy Fuels, 2020,4, 3400-3408 10.1039/D0SE00164C
- [8] An analysis of the WTC fires using CIB correlations and simple modeling JGQuintiere 10.1177/0734904121989670
- [9] Alternative donor substrates for inverting and retaining glycosyltransferases? Luke L. Lairson,Warren W. WakarchukChem. Commun., 2007, 365-367 10.1039/B614636H
- [10] An artificial photosynthetic system for photoaccumulation of two electrons on a fused dipyridophenazine (dppz)–pyridoquinolinone ligand? Philipp Traber,Stephan Kupfer,Stefanie Gr?fe,Isabelle Baussanne,Martine Demeunynck,Jean-Marie Mouesca,Serge Gambarelli,Vincent Artero,Murielle Chavarot-KerlidouChem. Sci., 2018,9, 4152-4159 10.1039/C7SC04348A
Journal Name：Food & Function
research_products
-
CAS no.: 89640-58-4
![N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide](https://ossimg.kuujia.com/scimg/1444500/1444113-98-7x500.png)
![1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol](https://ossimg.kuujia.com/scimg/1271000/1270529-38-8x500.png)
![2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid](https://ossimg.kuujia.com/scimg/2138500/2138166-62-6x500.png)
![2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide](https://ossimg.kuujia.com/scimg/2034500/2034271-14-0x500.png)