An intracellular buildup reaction of active siRNA species from short RNA fragments?

Chemical Communications Pub Date: 2013-11-29 DOI: 10.1039/C3CC47529H

Abstract

Here we report a new strategy for the buildup reaction of active siRNA species from short RNA fragments in living cells using a chemical ligation reaction. This strategy could decrease undesired immune responses and provide more latitude for RNAi technology in the design and concentration of introduced RNA compared to traditional siRNA methods.

Graphical abstract: An intracellular buildup reaction of active siRNA species from short RNA fragments
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