Rhodium-catalyzed C7-alkylation of indolines with maleimides?

Organic & Biomolecular Chemistry Pub Date: 2018-01-03 DOI: 10.1039/C7OB03039H

Abstract

A rhodium(III)-catalyzed direct cross-coupling reaction of indolines with maleimides via C–H bond activation was developed. This protocol displays good functional group tolerance, which offers a novel approach to access C7 modified indoline derivatives including maleimide analogues.

Graphical abstract: Rhodium-catalyzed C7-alkylation of indolines with maleimides
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