Regioselective synthesis of 2,3′-biindoles mediated by an NBS-induced homo-coupling of indoles?

Organic & Biomolecular Chemistry Pub Date: 2017-10-31 DOI: 10.1039/C7OB02312J

Abstract

Mild conditions have been developed to achieve NBS-induced homodimerization of indole derivatives with excellent regioselectivity at 15 °C in high efficiency. This method provides a simple route to a 2,3′-linked biindolyl scaffold from the electron-rich to moderately electron-poor indoles. In addition, [3,2-a]carbazole derivatives can also be prepared through this method.

Graphical abstract: Regioselective synthesis of 2,3′-biindoles mediated by an NBS-induced homo-coupling of indoles
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