Recent developments and applications of the Cadiot–Chodkiewicz reaction
Organic & Biomolecular Chemistry Pub Date: 2015-05-08 DOI: 10.1039/C5OB00697J
Abstract
The classical heterocoupling of a 1-haloalkyne with a terminal alkyne catalyzed by copper salts in the presence of a base for the synthesis of unsymmetrical diynes is termed the Cadiot–Chodkiewicz coupling reaction. The diynes are of great importance due to their biological, optical and electronic properties. A number of modifications have been developed recently to improve the efficiency of Cadiot–Chodkiewicz coupling reactions in terms of selectivity and yield. This is the first review on the Cadiot–Chodkiewicz cross-coupling reaction which highlights the modern approaches and protocols developed for the synthesis and applications of unsymmetrical 1,3-diynes.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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