Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides?
Organic & Biomolecular Chemistry Pub Date: 2017-11-09 DOI: 10.1039/C7OB02043K
Abstract
A facile domino reaction of 2-chloroquinoline-3-carbaldehydes in one and two equivalents of isocyanide has been investigated. Three-component reactions of 2-chloroquinoline-3-carbaldehydes, isocyanides and amines are also described. In this Pd-catalyzed reaction under controlled conditions, three novel types of quinoline derivatives were formed via amidation, lactamization or carbamate formation along with the formation of C–C, C–N, and C–O bonds in a one-pot procedure.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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