Palladium-catalyzed paraformaldehyde insertion: a three-component synthesis of benzofurans?

Organic & Biomolecular Chemistry Pub Date: 2016-02-04 DOI: 10.1039/C6OB00198J

Abstract

An efficient procedure for 2-aroylbenzofuran preparation from 2-bromophenols, phenacyl bromides and paraformaldehyde is described. The cheap and stable paraformaldehyde served as the carbon source via an in situ formylation reaction.

Graphical abstract: Palladium-catalyzed paraformaldehyde insertion: a three-component synthesis of benzofurans
Recommended Literature