Nucleophilic amination of methoxypyridines by a sodium hydride–iodide composite?

Chemical Communications Pub Date: 2018-08-16 DOI: 10.1039/C8CC05979A

Abstract

A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). The method offers a concise access to various aminopyridines which are potentially of medicinal interest.

Graphical abstract: Nucleophilic amination of methoxypyridines by a sodium hydride–iodide composite
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