New, simple and versatile synthesis of 4,6-disubstituted pyridazin-3(2H)-ones?
Organic & Biomolecular Chemistry Pub Date: 2008-02-28 DOI: 10.1039/B718734C
Abstract
A simple, two-step synthesis of 4,6-disubstituted pyridazin-3(2H)-ones starting from 2-diethoxyphosphoryl-4-oxoalkanoates and hydrazines is described. The intermediate 4-diethoxyphosphoryl-4,5-dihydropyridazin-3(2H)-ones obtained in this way are used in a Horner–Wadsworth–Emmons olefination of aldehydes to give a variety of disubstituted pyridazin-3(2H)-ones.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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