An experimental screen for quinoline/fumaric acid salts and co-crystals?

CrystEngComm Pub Date: 2012-01-13 DOI: 10.1039/C2CE06439A

Abstract

An experimental screen has been carried out for salts and co-crystals of quinoline (C9H7N) and fumaric acid (C4H4O4), including solution-based co-crystallisation from a variety of solvents, solvent-assisted and solvent-free co-grinding, and direct co-crystallisation of the starting materials. Characterised products include the previously published 1?:?1 salt, C9H8N+·C4H3O4?, and a new 2?:?1 quinoline/fumaric acid co-crystal, (C9H7N)2·C4H4O4. Attempts to influence the crystallisation outcome by addition of 6-methylquinoline yielded a second co-crystal, also with an inherent 2?:?1 quinoline/fumaric acid ratio, as a solid solution containing ca. 75% 6-methylquinoline and 25% quinoline. The corresponding co-crystal with pure 6-methylquinoline, (C10H9N)2·C4H4O4, was prepared, but the analogous structure with pure quinoline could not be obtained. Energy minimisation using dispersion-corrected density functional theory (DFT-D) calculations suggests that the hypothetical polymorph of the 2?:?1 quinoline/fumaric acid co-crystal derived from the structure of the 2?:?1 6-methylquinoline/fumaric acid co-crystal is ca. 8 kJ mol?1 less stable than the structure that is actually observed.

Graphical abstract: An experimental screen for quinoline/fumaric acid salts and co-crystals
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