Interrupted aza-Wittig reactions using iminophosphoranes to synthesize 11C–carbonyls?
Chemical Communications Pub Date: 2021-05-04 DOI: 10.1039/D1CC01016F
Abstract
A direct CO2-fixation methodology couples structurally diverse iminophosphoranes with various nucleophiles to synthesize ureas, carbamates, thiocarbamates, and amides, and is amenable for 11C radiolabeling. This methodology is practical, as demonstrated by the synthesis of >35 products and isolation of the molecular imaging radiopharmaceuticals [11C]URB694 and [11C]glibenclamide.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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