Enantioselective oxidation of secondary alcohols by Candida parapsilosis ATCC 7330
RSC Advances Pub Date: 2013-11-21 DOI: 10.1039/C3RA46206D
Abstract
Optically pure allylic alcohols and 4-phenylbutan-2-ols were prepared by oxidative kinetic resolution using whole cells of Candida parapsilosis ATCC 7330. Only the ‘S’ enantiomer is selectively oxidized to the corresponding keto compound (yield, 37–46%) leaving the ‘R’ alcohol (yield, 37–52% and ee 46 to >99%). The biocatalytic method is carried out under mild conditions at 20 °C, pH 6.5 in phosphate buffer.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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