Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity?
Chemical Communications Pub Date: 2021-05-21 DOI: 10.1039/D1CC01405F
Abstract
We designed a new caging group that can be photoactivated only in the presence of a non-endogenous enzyme when exposed to 405 nm light. Because cells or tissues can be genetically tagged by an exogenously expressed enzyme, this novel method can serve as a strategy for adding targeting abilities to photocaged compounds.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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