Demethylation of 2,4-dimethoxyquinolines: the synthesis of atanine

Organic & Biomolecular Chemistry Pub Date: 2003-11-06 DOI: 10.1039/B311281K

Abstract

The synthesis of the quinoline alkaloid atanine 6, by selective demethylation of the 2,4-dimethoxyquinoline 11 is presented. An alternative demethylation utilising a thiolate anion leads to the regioisomeric 4-hydroxyquinoline 13.

Graphical abstract: Demethylation of 2,4-dimethoxyquinolines: the synthesis of atanine
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