CsOH/γ-Al2O3: a heterogeneous reusable basic catalyst for one-pot synthesis of 2-amino-4,6-diaryl pyrimidines?

New Journal of Chemistry Pub Date: 2016-01-13 DOI: 10.1039/C5NJ03565A

Abstract

A new strategy for a one-pot synthesis of 2-amino-4, 6-diaryl pyrimidines using CsOH/γ-Al2O3 as a heterogeneous, reusable basic catalyst is presented. The developed synthetic protocol for pyrimidines is a one-pot three-component reaction of acetophenone, aromatic aldehydes and guanidine hydrochloride in ethanol. Characterization of the catalyst CsOH/γ-Al2O3 was performed by using FT-IR, XRD, TG-DTA, SEM, BET surface area and CO2-TPD analysis techniques. The analytical data prove that the catalyst has excellent reusability and also indicate their good thermal stability.

Graphical abstract: CsOH/γ-Al2O3: a heterogeneous reusable basic catalyst for one-pot synthesis of 2-amino-4,6-diaryl pyrimidines
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