Copper-mediated C(sp3)–H azidation with Me3SiN3: synthesis of imidazoles from ketones and aldehydes?
Chemical Communications Pub Date: 2016-04-18 DOI: 10.1039/C6CC01863G
Abstract
The efficient construction of 2,4,5-trisubstituted imidazoles, through a copper-mediated three-component reaction involving ketones, aldehydes, and Me3SiN3, has been developed. During the process, 4 C–N bonds were formed sequentially. Experimental results and DFT calculations suggested that azidation of the alpha methylene group of the ketone was the key C–N bond-forming step.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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