Copper catalyzed synthesis of fused benzimidazolopyrazine derivatives via tandem benzimidazole formation/annulation of δ-alkynyl aldehyde?
Organic & Biomolecular Chemistry Pub Date: 2013-08-14 DOI: 10.1039/C3OB41044G
Abstract
A novel route to synthesize the biologically active benzimidazolopyrazine core is outlined. The reaction proceeds via tandem benzimidazole formation/annulations of indole, pyrrole and aliphatic δ-alkynyl aldehydes in the presence of copper salts and green solvents with moderate to good yields.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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