Copper catalyzed oxidative coupling of amines with formamides: a new approach for the synthesis of unsymmetrical urea derivatives?

Chemical Communications Pub Date: 2013-06-04 DOI: 10.1039/C3CC42381F

Abstract

Direct access to unsymmetrical urea derivatives via copper catalysed C–H/N–H coupling of formamides with amines has been developed at room temperature. This protocol is also applied to the synthesis of chiral urea derivatives.

Graphical abstract: Copper catalyzed oxidative coupling of amines with formamides: a new approach for the synthesis of unsymmetrical urea derivatives
Recommended Literature