Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

Reaction Chemistry & Engineering Pub Date: 2020-05-26 DOI: 10.1039/D0RE00087F

Abstract

During the past two decades, continuous flow chemistry has been developed into a mature field as shown by numerous examples in which complex molecules are synthesised. In this review we discuss recent one-flow multistep syntheses to produce active pharmaceutical ingredients (APIs) including challenges and solutions that have been encountered.

Graphical abstract: Continuous one-flow multi-step synthesis of active pharmaceutical ingredients
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