Use of thermochromism of associates for the determination of antihistamine drugs in pharmaceutical preparations and urine
ANALYSTANALYST Pub Date: DOI: 10.1039/AN9820700634
Abstract
A sensitive and selective spectrophotometric method has been developed for the assay of diphenhydramine and chlorpheniramine maleate in pharmaceutical preparations and urine. The method depends on ion-pair extraction and thermochromism of associates formed between tertiary amines and tetrabromophenolphthalein ethyl ester (TBPE). The method obeys Beer's law in the concentration range 1 × 10–6–5 × 10–6M(0.2918–1.459 μg ml–1) of diphenhydramine and 1 × 10–6–5 × 10–6M(0.391–1.950 μg ml–1) of chlorpheniramine maleate. The proposed method can be applied to the determination of diphenhydramine and chlorpheniramine maleate with quaternary ammonium salts in pharmaceuticals of the ointment and liquid types and chlorpheniramine maleate in urine. Thermochromism of associates with amines was also investigated.
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CAS no.: 89640-58-4
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