Aminoindanol-based chiral derivatizing agents for the determination of the absolute configuration of carboxylic acids?

Organic & Biomolecular Chemistry Pub Date: 2012-08-23 DOI: 10.1039/C2OB26168E

Abstract

New chiral derivatizing agents have been prepared through a simple, short-step synthesis. The absolute configuration of α-chiral carboxylic acids can be assigned on the basis of the NMR chemical shift difference between diastereomeric esters. Because of the modular structures of the agents, the anisotropic effect could be easily manipulated to afford large chemical shift differences even in polar solvents.

Graphical abstract: Aminoindanol-based chiral derivatizing agents for the determination of the absolute configuration of carboxylic acids
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