Transition metal-catalyzed functionalization of pyrazines

Organic & Biomolecular Chemistry Pub Date: 2013-04-09 DOI: 10.1039/C3OB40460A

Abstract

Transition metal-catalyzed reactions are generally used for carbon–carbon bond formation on pyrazines and include, but are not limited to, classical palladium-catalyzed reactions like Sonogashira, Heck, Suzuki, and Stille reactions. Also a few examples of carbon–heteroatom bond formation in pyrazines are known. This perspective reviews recent progress in the field of transition metal-catalyzed cross-coupling reactions on pyrazine systems. It deals with the most important C–C- and C–X-bond formation methodologies.

Graphical abstract: Transition metal-catalyzed functionalization of pyrazines
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