Versatile symport transporters based on cyclic peptide dimers?

Chemical Communications Pub Date: 2019-11-15 DOI: 10.1039/C9CC06644F

Abstract

We present the synthesis and transmembrane transport properties of a new family of tris-pyridine-decorated cyclic peptides. These molecules are designed to self-assemble into dimeric shuttles in nonpolar media, which act as symport ionophores in which, apparently, the tris-pyridine scaffold complexes both cations and anions with high potency and efficacy.

Graphical abstract: Versatile symport transporters based on cyclic peptide dimers
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