Total synthesis of strobilurin B using a hetero-bis-metallated pentadiene linchpin?

Chemical Communications Pub Date: 2005-12-06 DOI: 10.1039/B514233D

Abstract

An efficient, six-step stereocontrolled total synthesis of the antifungal agent strobilurin B is reported and was based on a convergent bi-directional coupling featuring a hetero-bis-1,4-metallated pentadiene system as the linchpin.

Graphical abstract: Total synthesis of strobilurin B using a hetero-bis-metallated pentadiene linchpin
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