Total synthesis of (±)-rhazinal, an alkaloidal spindle toxin from Kopsia teoi

Organic & Biomolecular Chemistry Pub Date: 2002-12-19 DOI: 10.1039/B209992F

Abstract

The title alkaloid 1 and its B-nor-congener 3, both of which display potent and unusual anti-mitotic properties, have been synthesized in racemic form and characterised by single-crystal X-ray analysis.

Graphical abstract: Total synthesis of (±)-rhazinal, an alkaloidal spindle toxin from Kopsia teoi
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