Total synthesis of (-)-PA-48153C (pironetin) utilising l-quebrachitol as a chiral building block

Chemical Communications Pub Date: 1900-01-01 DOI: 10.1039/A701404J

Abstract
The chiral and stereoselective synthesis of (-)-PA-48153C (pironetin) 1, a novel immunosuppressant, is described; the acyclic portion possessing four contiguous chiral centres in 1 was constructed stereoselectively from L-quebrachitol and the 2-pyranone moiety was prepared from L-malic acid.
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