Total synthesis and structural revision of (±)-nidemone?
Organic & Biomolecular Chemistry Pub Date: 2018-06-19 DOI: 10.1039/C8OB01207E
Abstract
Total synthesis of the revised structure of (±)-nidemone has been accomplished from 6-bromo-2-hydroxybenzaldehyde (5) in either six or eight synthetic steps in 6% and 10% overall yield, respectively, without using any protecting group. The revised structure of nidemone was confirmed by single-crystal X-ray diffraction analysis. Sonogashira coupling, regioselective hydrogenation, and an intramolecular Stetter reaction were the key steps in the synthesis.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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