Alkyne aminohalogenation enabled by DBU-activated N-haloimides: direct synthesis of halogenated enamines?
Chemical Communications Pub Date: 2014-01-08 DOI: 10.1039/C3CC49572H
Abstract
Activated by DBU, N-haloimides can be used as both halogen and nitrogen sources to achieve the difunctionalization of terminal alkynes, giving rise to useful halogenated enamines with high efficiency and high regio- and stereoselectivities. The cascade reaction features simple manipulation, mild conditions, a broad substrate scope, readily available reagents, and atom-economy.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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