The first example of the direct asymmetric conjugate addition of aldehydes to a methylenemalonate promoted by an axially chiral amino diol catalyst?

Chemical Science Pub Date: 2011-08-26 DOI: 10.1039/C1SC00453K

Abstract

A methylenemalonate could be employed as a reactive equivalent of a three carbon Michael acceptor such as acrylate in a direct asymmetric conjugate addition of aldehydes catalyzed by an axially chiral amino diol. The obtained conjugate addition product was readily converted to synthetically useful and important chiral building blocks.

Graphical abstract: The first example of the direct asymmetric conjugate addition of aldehydes to a methylenemalonate promoted by an axially chiral amino diol catalyst
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