The chiral drug Albicar: resolution of its racemate via complexation with BINOL??

New Journal of Chemistry Pub Date: 2010-01-27 DOI: 10.1039/B9NJ00701F

Abstract

Both enantiomers of the title drug (2,6-diethyl-4,8-dimethylglycoluril; 1) were prepared from their complexes with (R)- and (S)-BINOL in 59% ((+)-1) and 43% ((?)-1) yield from its racemate. The absolute configuration of (1R,5R)-(+)-1 was determined by an XRD study of the (R)-(+)-BINOL-(+)-1·H2O complex.

Graphical abstract: The chiral drug Albicar: resolution of its racemate via complexation with BINOL
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