Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex?
Chemical Communications Pub Date: 2017-04-21 DOI: 10.1039/C7CC01376K
Abstract
Proteins typically carry out their biological functions as multi-protein complexes, which can significantly affect the affinity of small-molecule inhibitors. HSP70 is an important target in oncology, so to study its chemical biology and the drug discovery potential of the HSP70/BAG1 complex, we designed a high-affinity non-nucleotide fluorescence polarisation probe.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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