Synthesis of (phosphonomethyl)phosphinate pyrophosphate analogues via the phospha-Claisen condensation?

Organic & Biomolecular Chemistry Pub Date: 2014-11-06 DOI: 10.1039/C4OB02007C

Abstract

Pyrophosphate analogues are of great importance especially for the design of biologically active molecules. The phospha-Claisen condensation allows for the rapid synthesis of (phosphonomethyl)phosphinate pyrophosphate analogues and building blocks that can be employed in numerous applications.

Graphical abstract: Synthesis of (phosphonomethyl)phosphinate pyrophosphate analogues via the phospha-Claisen condensation
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