Synthesis aided structural determination of amyloid-β(1–15) glycopeptides, new biomarkers for Alzheimer's disease?
Chemical Communications Pub Date: 2014-10-09 DOI: 10.1039/C4CC05085A
Abstract
Unique tyrosine glycosylated amyloid-β(1–15) glycopeptides were synthesized with well-defined stereochemistry at the glycosidic linkages. Aided by these glycopeptides and tandem mass spectrometry analysis, the naturally existing amyloid-β glycopeptides, isolated from Alzheimer's disease patients, were determined to contain an α-linked N-acetyl galactosamine at the modified tyrosine 10 residue. Glycosylation can significantly impact the properties of amyloid-β as the glycopeptide has much lower affinity for Cu+ ions.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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