Synthesis of arylacetonitrile derivatives: Ni-catalyzed reaction of benzyl chlorides with trimethylsilyl cyanide under base-free conditions?

RSC Advances Pub Date: 2014-03-21 DOI: 10.1039/C4RA01153H

Abstract

We developed a simple strategy for the synthesis of arylacetonitriles from benzyl chlorides and trimethylsilyl cyanide using a Ni(cod)2/PPh3 catalyst.

Graphical abstract: Synthesis of arylacetonitrile derivatives: Ni-catalyzed reaction of benzyl chlorides with trimethylsilyl cyanide under base-free conditions
Recommended Literature