Synthesis of 2-substituted-3-(1H-indol-3-yl)isoindolin-1-one derivatives in water under catalyst-free conditions?
Green Chemistry Pub Date: 2014-02-13 DOI: 10.1039/C3GC41882K
Abstract
A series of 3-(1H-indol-3-yl)isoindolin-1-one derivatives were synthesized by the three-component reaction of a phthalaldehydic acid, primary amine, and 1H-indole in water under catalyst-free conditions. The reaction presented here has several advantages, such as clean, one-pot, and easy handling. The environmentally-friendly features make this procedure a sustainable method for the synthesis of 3-(1H-indol-3-yl)isoindolin-1-ones.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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