Synthesis of endoperoxides by domino reactions of ketones and molecular oxygen??

RSC Advances Pub Date: 2015-11-13 DOI: 10.1039/C5RA13476E

Abstract

Domino reactions of ketones with molecular oxygen in the presence of potassium hydroxide and potassium t-butoxide afford cyclic hydroperoxy acetals (3,5-dihydroxy-1,2-dioxanes). Mixed endoperoxides can also be obtained in a three-component reaction of two ketones and oxygen.

Graphical abstract: Synthesis of endoperoxides by domino reactions of ketones and molecular oxygen
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